Patent · US Active

Process for the production of dronedarone intermediates

US8658808B2 · kind B2 · utility

13Cited by

3References

12Claims

0Family size

Assignee

Sanofi · FR

Inventors

Gerhard Kretzschmar · Eschborn, DE
Volker Kraft · Frankfurt am Main, DE
Kai Rossen · Hanau, DE
Joachim Graeser · Kelsterbach, DE

Key dates

Filing date	May 26, 2010
Grant date	Feb 25, 2014
Priority date	—
Expiry date	Nov 20, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P9/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the production of Dronedarone intermediates of the formula (I), by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-(4-methoxyphenyl)-ethanone, subsequent treatment of the ester with bases and a zeolite (alumosilicate) catalyst and optional subsequent demethylation. This process can be used for the production of Dronedarone.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.