Enzymatic peracid generation for use in oral care products

US8663616B2 · kind B2 · utility

Assignee

• E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

• Lisa A. Butterick · Swedesboro, US
• Scott Cunningham · Chadds Ford, US
• Robert DiCosimo · Chadds Ford, US
• Kari A. Fosser · Folsom, US
• Tanja Maria Gruber · Media, US
• Sharon L. Haynie · Philadelphia, US
• Mark S. Payne · Wilmington, US
• Pierre E. Rouviere · Wilmington, US
• Hong Wang · Kennett Square, US

Key dates

• Filing date: Dec 19, 2011
• Grant date: Mar 4, 2014
• Expiry date: Jun 13, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.