Intraoperative trifunctional antibody application for prophylaxis of intraperitoneal tumor cell dissemination

US8663638B2 · kind B2 · utility

Assignee

• Trion Pharma GmbH · DE

Inventors

• Horst Lindhofer · Puchheim, DE
• Markus M. Heiss · Cologne, DE

Key dates

• Filing date: Sep 4, 2008
• Grant date: Mar 4, 2014
• Expiry date: Aug 8, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes the use of trifunctional bispecific and trispecific antibodies for destroying tumor cells which e.g. are disseminated intraperitoneally due to a surgical intervention, wherein the antibody is administered intraoperatively, preferably directly locally into the abdominal cavity.