Diazo bicyclic Smac mimetics and the uses thereof

US8664212B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Yuefeng Peng · Ann Arbor, US
• Haiying Sun · Ann Arbor, US
• Qian Cai · Ann Arbor, US
• Zaneta Nikolovska-Coleska · Ann Arbor, US
• Jianfeng Lu · Ann Arbor, US
• Su Qiu · Ann Arbor, US

Key dates

• Filing date: Jul 25, 2012
• Grant date: Mar 4, 2014
• Expiry date: Jul 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to diazo bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.