Substituted 5H-pyrimido[5,4-B]indoles, method for the production thereof and use thereof for treating non-solid malignant tumors of the blood-producing system

US8664233B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Claudia Reichelt · Leipzig, DE
• Alexander Schulze · Bad Liebenwerda, DE
• Mohammed Daghish · Leipzig, DE
• Friedrich-Alexander Ludwig · Leipzig, DE
• Jochen Heinicke · Leipzig, DE
• Konrad Herrmann · Leipzig, DE
• Maj Schuster · Leipzig, DE
• Sven Letschert · Leipzig, DE
• Kenneth Mugridge · Siena, IT
• Joseph DeAngelo · Hamtramck, US

Key dates

• Filing date: Dec 21, 2007
• Grant date: Mar 4, 2014
• Expiry date: Apr 14, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of general formula 1to processes for the production thereof, to pharmaceutical preparations containing said compounds and/or physiologically compatible salts and/or solvates which can be produced therefrom as well as to the pharmaceutical use of said compounds, the salts or solvates thereof as inductors of apoptosis in the case of non-solid malignant tumors of the hematopoietic system, in particular in the case of leukemias and lymphomas, more particularly in the case of leukemic B lymphocytes.