Indenoisoquinolinone derivatives, manufacturing method and medical use thereof

US8664238B2 · kind B2 · utility

Assignees

• CHINA PHARMACEUTICAL UNIVERSITY · CN
• Nanjing Medical University Affiliated Brain Hospital · CN

Inventors

• Hua Xiang · 安丰镇, CN
• Tianlin Wang · Shanghai, CN
• Hong Xiao · Pleasanton, US
• Qidong You · 安丰镇, CN
• Yao Yao · San Mateo, US
• Xiaobo Li · Shanghai, CN
• Qingjiang Liao · 安丰镇, CN

Key dates

• Filing date: Dec 16, 2009
• Grant date: Mar 4, 2014
• Expiry date: Dec 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.