Solvent resistant diafiltration of peptides, PNA or oligonucleotides
US8664357B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2009 |
| Grant date | Mar 4, 2014 |
| Priority date | — |
| Expiry date | Sep 4, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesizing the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.