Patent · US Active

Process for the introduction of hydroxyethoxy side chain in bosentan

US8664390B2 · kind B2 · utility

0Cited by

4References

4Claims

0Family size

Assignee

Generics [UK] Limited · GB

Inventors

Abhay Gaitonde · Jamkhed, IN
Bindu Manojkumar · Jamkhed, IN
Sandeep Sonawane · Jamkhed, IN
Dattatrey Kokane · Jamkhed, IN
Sandeep Mekde · Jamkhed, IN
Dattatraya Shinde · Jamkhed, IN
Prakash Bansode · Hyderabad, IN

Key dates

Filing date	Jun 27, 2008
Grant date	Mar 4, 2014
Priority date	—
Expiry date	Sep 12, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P11/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.