Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib

US8664402B2 · kind B2 · utility

Assignee

• F.I.S. Fabbrica Italiana Sintetici S.p.A. · IT

Inventors

• Andrea Castellin · Rubano, IT
• Paolo Stabile · Montecchio Maggiore, IT
• Francesco Fontana · Longone al Segrino, IT
• Ottorino De Lucchi · Montecchio Maggiore, IT
• Andrea Caporale · Vicenza, IT
• Stefano Tartaggia · Vicenza, IT

Key dates

• Filing date: Jan 11, 2012
• Grant date: Mar 4, 2014
• Expiry date: Jan 29, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/50
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.