Patent · US Active

Recombinant soluble FC receptors

US8666680B2 · kind B2 · utility

1Cited by

7References

2Claims

0Family size

Assignee

Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

Peter Sondermann · Stockdorf, DE
Robert Huber · Midland, US
Uwe Jacob · Birkenfeld, DE

Key dates

Filing date	Oct 13, 2011
Grant date	Mar 4, 2014
Priority date	—
Expiry date	Oct 13, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2299/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycoslyation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host ells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modeling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that an be used to separate and/or enrich antibodies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.