Patent · US Active

Structure of the C-terminal region of the insulin receptor α-chain and of the insulin-like growth factor receptor α-chain

US8666718B2 · kind B2 · utility

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11Claims

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Assignee

THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

Michael Colin Lawrence · Mona Vale, AU
Brian John Smith · Melbourne, AU
John Gerbrandt Tasman Menting · Melbourne, AU
Colin Wesley Ward · Melbourne, AU

Key dates

Filing date	Mar 9, 2010
Grant date	Mar 4, 2014
Priority date	—
Expiry date	Mar 9, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG16B5/00
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.