Methods for treating glaucoma and macular degeneration
US8669253B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Mar 12, 2007 |
| Grant date | Mar 11, 2014 |
| Priority date | — |
| Expiry date | Dec 13, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/168
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration. The GGTase-I enzyme is a molecular target for lowering increased ocular pressure in glaucoma patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.