Patent · US Active

Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof

US8669260B2 · kind B2 · utility

0Cited by

4References

14Claims

0Family size

Assignee

ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY · US

Inventors

Sridhar Mani · Riverdale, US
Bhaskar C. Das · West Nyack, US

Key dates

Filing date	Jan 27, 2009
Grant date	Mar 11, 2014
Priority date	—
Expiry date	Aug 31, 2029

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.