Removal of endotoxin using amphiphilic core-shell nanosorbents

US8669354B2 · kind B2 · utility

Assignee

• The Hong Kong Polytechnic University · CN

Inventors

• Pei Li · Hong Kong, CN
• Kin Man Ho · Hong Kong, CN

Key dates

• Filing date: Jun 20, 2011
• Grant date: Mar 11, 2014
• Expiry date: Jun 20, 2031

Classification

• Technology area (CPC H): Electricity
• CPC primary: H01F1/0054
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

Method for removal of endotoxin from protein preparations using core-shell nanoparticles, which have the ability to selectively adsorb endotoxin molecules in a protein mixture. The method comprises the steps of (a) preparing a plurality of core-shell nanoparticles; (b) adding the core-shell nanoparticles into a protein preparation containing endotoxin; (c) incubating the core-shell nanoparticles with the protein preparation for a period of time; and (d) separating nanoparticles from the protein preparation.