Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease
US8670941B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Aug 17, 2007 |
| Grant date | Mar 11, 2014 |
| Priority date | — |
| Expiry date | Jul 28, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2821
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are methods of diagnosing Alzheimer's disease (“AD”) based on characteristic changes of the levels of certain free amino acids or dipeptides (collectively termed as “AD diagnosis markers”) in the body fluid sample of an individual, carnosine synthesis activities in the plasma, and dopamine synthesis activities in the plasma. Also provided are methods of simultaneously determining the levels of at least two free amino acids or dipeptides in the biological fluid sample of an individual.
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