Cell penetrating peptides and its use fused to biomolecules with therapeutic action

US8673313B2 · kind B2 · utility

Assignee

• CENTRO DE INGENIERÍA GENÉTICA Y BIOTECNOLOGÍA · CU

Inventors

• Isis del Carmen Torrens Madrazo · Boyeros, CU
• Maribel Guerra Vallespi · Boyeros, CU
• Milaid Granadillo Rodriguez · Boyeros, CU
• Osvaldo Reyes Acosta · Havana, CU
• Boris Ernesto Acevedo Castro · Boyeros, CU

Key dates

• Filing date: Jul 31, 2008
• Grant date: Mar 18, 2014
• Expiry date: Sep 14, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.