Immunoglobulin affinity ligand
US8674073B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 2007 |
| Grant date | Mar 18, 2014 |
| Priority date | — |
| Expiry date | Aug 31, 2029 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/3809
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Provided is affinity chromatography carrier for an immunoglobulin that simultaneously has high immunoglobulin-binding capability and chemical stability and that can be produced at low cost. An immunoglobulin-binding protein in which an amino acid substitution for not only maximizing the number of lysine residues on the protein surface of helix 3 and its periphery but also minimizing the number of lysine residues present on the protein surfaces of helix 1 and helix 2 as immunoglobulin-binding regions and/or an amino acid substitution for eliminating an aspartic acid-proline sequence have (has) been carried out, or a multimer thereof, is used as an affinity ligand for an affinity chromatography carrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.