Patent · US Active

Nucleotides and oligonucleotides for nucleic acid sequencing

US8674086B2 · kind B2 · utility

17Cited by

1References

14Claims

0Family size

Assignee

Intel Corporation · US

Inventors

Jianquan Liu · Fremont, US
Xing Su · Cupertino, US
Kai-Chiang Wu · Hsinchu, TW

Key dates

Filing date	Jun 25, 2010
Grant date	Mar 18, 2014
Priority date	—
Expiry date	Feb 7, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6874
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Embodiments of the invention provide non-natural bifunctional nucleotides having both nuclease resistance and nucleic acid synthesis blocking properties and methods of sequencing nucleic acids that employ non-natural bifunctional nucleic acids. Additional embodiments provide non-natural oligonucleotides and methods for sequencing nucleic acids using the non-natural oligonucleotides. Methods according to embodiments of the invention employ electronic detection and fluorescent detection of nucleic acid sequencing reactions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.