Patent · US Active

Process for the production of benzofurans

US8674121B2 · kind B2 · utility

13Cited by

3References

21Claims

0Family size

Assignee

Sanofi · FR

Inventors

Gerhard Kretzschmar · Eschborn, DE
Volker Kraft · Frankfurt am Main, DE
Thomas Olpp · Frankfurt am Main, DE
Kai Rossen · Hanau, DE

Key dates

Filing date	May 26, 2010
Grant date	Mar 18, 2014
Priority date	—
Expiry date	Nov 21, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C205/45
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.