N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
US8674132B2 · kind B2 · utility
34Cited by
12References
22Claims
0Family size
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Key dates
| Filing date | Jun 22, 2012 |
| Grant date | Mar 18, 2014 |
| Priority date | — |
| Expiry date | Jun 22, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.