Aromatic butan-2-ol compounds and preparation and uses thereof

US8674136B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Ping Liu · Shanghai, CN
• Junhai Xiao · Beijing, CN
• Zhibing Zheng · Beijing, CN
• Yunde Xie · Beijing, CN
• Guoming Zhao · Beijing, CN
• Xiaokui Wang · Beijing, CN
• Lili Wang · Beijing, CN
• Xingzhou Li · Beijing, CN
• Xinbo Zhou · Beijing, CN

Key dates

• Filing date: May 16, 2011
• Grant date: Mar 18, 2014
• Expiry date: May 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C215/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aromatic butan-2-ol compounds, preparation methods for making the compounds, and uses of the compounds are provided. Specifically, the compound of Formula I, or an optical isomer, racemate, diastereomer, pharmaceutically acceptable salt, or solvate thereof, is provided, where each of the substituents is defined. In addition, a pharmaceutical composition containing the compound, and the use of the compound in manufacture of a medicament for the treatment and/or prophylaxis of a disease or disorder caused by tubercle bacillus infection, is provided.