Large-collection-area raman probe with reduced background fluorescence
US8675190B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 2011 |
| Grant date | Mar 18, 2014 |
| Priority date | — |
| Expiry date | Sep 13, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/65
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A compact Raman analysis system combines a near-infrared (NIR) laser source, a 2D array collecting anti-Stokes Raman spectra, and a probe configured to measure complex solid samples, including pharmaceutical tablets and other large-area targets with reduced background fluorescence at relatively low cost. The system collects spectra from an area of 1-mm or greater, preferably 3-12 mm or more, facilitating the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.