Closed loop flow control of a HPLC constant flow pump to enable low-flow operation
US8679333B2 · kind B2 · utility
2Cited by
9References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 25, 2010 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Dec 22, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/324
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 μL/min) HPLC flow rates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.