Control system and method for flash separation
US8679345B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 1, 2010 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Jan 23, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/90
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are methods and apparatus for determining conditions for performing chromatography, particularly flash chromatography. The methods may be utilized for separating compounds in a sample in a column chromatography system. The method includes determining at least two retention factors corresponding to the TLC performance of a target compound and an adjacent compound and defining a sample loading amount and a solvent gradient profile using at least two solvents that will result in differential elution of the target and adjacent compounds from a chromatography column. The chromatography system and loading parameters may be selected to provide satisfactory separation of the target compound from adjacent compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.