High-yield method for the production of human antibodies blocking the biological activity of a human cytokine
US8679483B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Sep 15, 2004 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Nov 5, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/21
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a pharmaceutical composition comprising, as the active ingredient, human natural antibodies of the IgG isotype, that neutralize the activity of a human cytokine selected from VEGF, IFNα, IL-4, TNFα and TGFβ, the said neutralizing antibodies inhibiting at least 50% of the maximum biological activity induced by an amount ranging from 0.006 ng to 0.05 ng of the said cytokine in vitro.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.