Anti-ferroportin 1 monoclonal antibodies and uses thereof

US8679497B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Donmienne Doen Mun Leung · San Diego, US
• Peng Luan · Omaha, US
• Joseph Vincent Manetta · Indianapolis, US
• Ying Tang · San Diego, US
• Derrick Ryan Witcher · Fishers, US

Key dates

• Filing date: May 7, 2012
• Grant date: Mar 25, 2014
• Expiry date: Jul 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.