Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin
US8679738B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2012 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | May 27, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/62
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The presently described subject matter is directed to a water-soluble conjugated polyene compound and the derivatives thereof that exhibit aggregation induced emission, as well as any water dispersible, fluorescent, polymeric microparticles, nanoparticles, and/or pharmaceutical composition comprising the water-soluble conjugated polyene compound and/or the derivatives thereof. Also provided are methods of making and using the compound, derivatives and particles of the presently described subject matter. The presently described water-soluble conjugated polyene compound are useful as bioprobes for the detection of biomacromolecules, in the manufacture of sensors, in monitoring and retarding formation of amyloid protein fibril in vitro and in vivo, and in developing anti-cancer drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.