Compositions, devices, systems, for using a nanopore
US8679747B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 2009 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Jun 25, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/48721
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention herein disclosed provides for devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore in the absence of requiring a terminating nucleotide. The devices and methods are also used to determine rapidly (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of drug discovery, molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.