Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation

US8679749B2 · kind B2 · utility

Assignee

• THE UNIVERSITY OF CHICAGO · US

Inventors

• Benjamin S. Glick · Chicago, US
• Daniel E. Strongin · Chicago, US
• Robert Keenan · San Francisco, US
• Rita L. Strack · Towson, US
• Dibyendu Bhattacharyya · Oak Park, US

Key dates

• Filing date: Nov 3, 2008
• Grant date: Mar 25, 2014
• Expiry date: May 22, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/43595
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission spectra or increased brightness relative to a wild-type DsRed.