Universal fibronectin Type III binding-domain libraries
US8680019B2 · kind B2 · utility
1Cited by
33References
18Claims
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Key dates
| Filing date | Sep 18, 2009 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Sep 18, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2318/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.