Compositions of a peptide targeting system for treating cancer
US8680045B2 · kind B2 · utility
5Cited by
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19Claims
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Key dates
| Filing date | Nov 1, 2011 |
| Grant date | Mar 25, 2014 |
| Priority date | — |
| Expiry date | Nov 1, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/856
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific targeting peptides are fused to the core ELP structure by standard genetic engineering techniques. These targeting peptides confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.