Controlled release corticosteroid compositions and methods for the treatment of otic disorders

US8680083B2 · kind B2 · utility

Assignees

• OTONOMY, INC. · US
• The Regents of the University of California · US

Inventors

• Jay Lichter · Rancho Santa Fe, US
• Benedikt Vollrath · San Diego, US
• Andrew M. Trammel · Olathe, US
• Sergio G. Duron · San Diego, US
• Fabrice Piu · San Diego, US
• Luis A. Dellamary · San Marcos, US
• Qiang Ye · San Diego, US
• Carl Lebel · Malibu, US
• Michael Christopher Scaife · Pittsburgh, US
• Jeffrey P. Harris · Village of La Jolla, US

Key dates

• Filing date: Jul 25, 2011
• Grant date: Mar 25, 2014
• Expiry date: Jul 25, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).