Substituted aza-bicyclic imidazole derivatives useful as TRPM8 receptor modulators

US8680098B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Mark R. Player · Phoenixville, US
• Raul Calvo · Royersford, US
• Jinsheng Chen · Exton, US
• Sanath K. Meegalla · Boothwyn, US
• Daniel Parks · Linglestown, US
• William J. Parsons · Montgomery, US
• Scott Ballentine · Lansdale, US
• Shawn Branum · Raritan, US

Key dates

• Filing date: Feb 25, 2011
• Grant date: Mar 25, 2014
• Expiry date: Mar 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.