Bradykinin 1 receptor modulating compounds

US8680159B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Melanie Reich · Aachen, DE
• Stefan Schunk · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Jean De Vry · Stolberg, DE
• Christa Kneip · Aachen, DE
• Tieno Germann · Aachen, DE
• Michael Engels · Turnhout, BE

Key dates

• Filing date: Sep 22, 2011
• Grant date: Mar 25, 2014
• Expiry date: Nov 18, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted benzamide compounds corresponding to formula (I)in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.