Method and system for comprehensive patient-specific modeling of the heart

US8682626B2 · kind B2 · utility

Assignee

• Siemens Aktiengesellschaft · DE

Inventors

• Razvan Ioan Ionasec · Lawrenceville, US
• Ingmar Voigt · Erlangen, DE
• Viorel Mihalef · New Brunswick, US
• Sasa Grbic · Plainsboro, US
• Dime Vitanovski · Erlangen, DE
• Yang Wang · Plainsboro, US
• Yefeng Zheng
• Bogdan Georgescu · Plainsboro, US
• Dorin Comaniciu · Princeton Junction, US
• Puneet Sharma · Rahway, US
• Tommaso Mansi · Plainsboro, US

Key dates

• Filing date: Apr 20, 2011
• Grant date: Mar 25, 2014
• Expiry date: May 8, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H50/50
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific…