Durable film coating compositions having sustained slow-release capability, and methods of use therefor
US8684739B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2003 |
| Grant date | Apr 1, 2014 |
| Priority date | — |
| Expiry date | Jun 6, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a slow-release delivery vehicle for delivering at least one active ingredient into a film coating, comprising a population of stable, homogeneously-dispersed, porous polymeric or co-polymeric beads having a network of pores, wherein the at least one active ingredient is held within the bead particles and within the network of pores and slowly released by internal flow, and wherein the network of pores is substantially non-collapsible upon removal of the active ingredient. The porous co-polymer bead preparation comprises a continuous aqueous phase solution containing a monomeric mixture of at least one polyvinylaromatic monomer and at least one porogen forming a network that comprising (i) macropores; (ii) mesopores; (iii) micropores; and (iv) gel porosity. Also provided are methods of preparing the porous co-polymer bead preparation; and for its use as a slow-release delivery vehicle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.