Heterologous protection against Pasteurella multocida provided by P. multocida fur cells and the outer-membrane protein extracts thereof
US8685413B2 · kind B2 · utility
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Key dates
| Filing date | Jan 29, 2009 |
| Grant date | Apr 1, 2014 |
| Priority date | — |
| Expiry date | Jun 17, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/552
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to Pasteurella multocida mutants capable of providing heterologous protection against infection caused by virulent P. multocida . Said mutants are defective in fur ompH and fur ompH galE genes. The invention relates to Pasteurella multocida bacteria vaccine compositions containing fur ompH double mutants and fur ompH galE triple mutants obtained from P. multocida , or an extract of iron-regulated outer-membrane proteins (IROMPs) obtained from said mutants, and to an excipient and/or pharmaceutically acceptable adjuvants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.