Docosahexaenoic acid producing strains of yarrowia lipolytica
US8685682B2 · kind B2 · utility
1Cited by
18References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 2009 |
| Grant date | Apr 1, 2014 |
| Priority date | — |
| Expiry date | Feb 12, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23V2002/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.