Collection and methods for its use

US8685896B2 · kind B2 · utility

Assignee

• MORPHOSYS AG · DE

Inventors

• Markus Enzelberger · Gräfelfing, DE
• Stefanie Urlnger · Munich, DE
• Thomas Tiller · Munich, DE
• Josef Prassler · Germering, DE
• Tanja Herrmann · Munich, DE

Key dates

• Filing date: May 29, 2010
• Grant date: Apr 1, 2014
• Expiry date: Aug 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.