Opioid prodrugs with heterocyclic linkers
US8685916B2 · kind B2 · utility
25Cited by
10References
123Claims
0Family size
Assignee
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Key dates
| Filing date | Mar 8, 2012 |
| Grant date | Apr 1, 2014 |
| Priority date | — |
| Expiry date | Mar 8, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The embodiments provide prodrug compounds of Formulae I-XV. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XV that provides controlled release of an opioid. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.