6-pyridin-3-yl-3,4-dihydro-1h-quinolin-2-one derivatives and related compounds as inhibitors of the human aldosterone synthase CYP11B2

US8685960B2 · kind B2 · utility

Assignee

• ElexoPharm GmbH · DE

Inventors

• Rolf Hartmann · Saarburg, DE
• Ralf Heim · Riegelsberg, DE
• Simon Lucas · Wien, AT

Key dates

• Filing date: May 5, 2009
• Grant date: Apr 1, 2014
• Expiry date: Oct 24, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives for the treatment of hyperaldosteronism and/or disorders or diseases that are mediated by 11 β-hydroxylase (CYP11 B1).