Pyrimidine compounds as delta opioid receptor modulators

US8685990B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Steven J. Coats · McDonough, US
• Haiyan Bian · Princeton, US
• Peter J. Connolly · New Providence, US
• Gilles Bignan · Bound Brook, US
• Chaozhong Cai · North Wales, US
• Scott L. Dax · Landenberg, US
• Bart DeCorte · Raritan, US
• Shu-Chen Lin · Doylestown, US
• Li Liu · Doylestown, US
• Mark J. Macielag · Spring House, US
• Philip Pitis · Valley Forge, US
• Yue-Mei Zhang · Wellesley, US
• Bin Zhu · Spring House, US
• Wei He · Audubon, US

Key dates

• Filing date: Jul 25, 2013
• Grant date: Apr 1, 2014
• Expiry date: Jul 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, R2, R3, and L, A, and Ra are defined herein.