Heterocyclic compounds and their use as binding partners for 5-HT5 receptors

US8686002B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Wilhelm Amberg · Ludwigshafen, DE
• Astrid Netz · Mannheim, DE
• Andreas Kling · Mannheim, DE
• Michael Ochse · Wiesbaden, DE
• Udo Lange · Ludwigshafen, DE
• Charles W. Hutchins · Libertyville, US
• Francisco Javier Garcia-Ladona · Kandel, DE
• Wolfgang Wernet · Ludwigshafen, DE

Key dates

• Filing date: Aug 21, 2006
• Grant date: Apr 1, 2014
• Expiry date: Aug 20, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of general formula (I), corresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof and the prodrugs of said compounds. The invention also relates to the use of said compounds as binding partners for 5-HT5 receptors for treating diseases that are modulated by a 5-HT5 receptor activity, in particular, for treating neurodegenerative and neuropsychiatric disorders as well as signs, symptoms and dysfunctions.