Method of purifying a salt, sodium salt and disodium salt of pemetrexed
US8686140B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Oct 21, 2008 |
| Grant date | Apr 1, 2014 |
| Priority date | — |
| Expiry date | Jul 31, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
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