Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same

US8691184B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Haibin Zhou · Ann Arbor, US
• Jianfang Chen · Ann Arbor, US
• Angelo Aguilar · Ann Arbor, US
• Jennifer Lynn Meagher · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• Chao-Yie Yang · Hangzhou City, CN
• Liu Liu · San Diego, US
• Longchuan Bai · Ann Arbor, US
• Donna McEachem · Ann Arbor, US
• Jeanne Stuckey · Fenton, US
• Xiaoqin Li · Ann Arbor, US

Key dates

• Filing date: Jan 24, 2012
• Grant date: Apr 8, 2014
• Expiry date: Jan 24, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.