Synthetic diblock copolypeptide hydrogels for use in the central nervous system

US8691204B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Timothy J. Deming · Summerland, US
• Michael V. Sofroniew · Los Angeles, US
• Chu-Ya Yang · Pingzhen District, TW
• BingBing Song · Los Angeles, US
• Yan Ao · Lomita, US

Key dates

• Filing date: Feb 18, 2010
• Grant date: Apr 8, 2014
• Expiry date: Dec 8, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active material that is mixed with the hydrogel or that is attached to the polypeptide chain of the hydrogel, wherein the composition is suitable for administration to the CNS. Also disclosed are methods of making and using compositions of the invention as depots or as scaffolds for cell migration, and pharmaceutical compositions and kits for implementing methods of the invention.