Implantable or insertable medical devices for controlled drug delivery

US8691264B2 · kind B2 · utility

Assignee

• Boston Scientific Scimed, Inc. · US

Inventors

• Jianmin Li · Lexington, US
• Danielle Conley · Waltham, US
• Weenna Bucay-Couto · Burlington, US
• Cang D. Dao · Foxborough, US
• Hamid Davoudi · Westwood, US
• Raymond Lareau · Westford, US
• Kathleen M. Miller · Shrewsbury, US

Key dates

• Filing date: Feb 24, 2012
• Grant date: Apr 8, 2014
• Expiry date: Jun 16, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/602
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Implantable or insertable medical devices are provided, which comprises: (a) a biocompatible polymer; and (b) at least one therapeutic agent selected from an anti-inflammatory agent, an analgesic agent, an anesthetic agent, and an antispasmodic agent. The medical devices are adapted for implantation or insertion at a site associated with pain or discomfort upon implantation or insertion. In many embodiments, the therapeutic will be selected from at least one of (i) ketorolac and pharmaceutically acceptable salts thereof (e.g., ketorolac tromethamine) and (ii) 4-diethylamino-2-butynylphenylcyclohexyl glycolate and pharmaceutically acceptable salts thereof (e.g., oxybutynin chloride). Also provided are uses for the implantable or insertable medical devices, which uses comprise reducing pain or discomfort accompanying the implantation or insertion of such devices. Further uses may comprise reducing microbial buildup along the device. Methods for manufacturing implantable or insertable medical devices are also provided.