Methods for early detection of blood disorders
US8691515B2 · kind B2 · utility
2Cited by
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17Claims
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Key dates
| Filing date | Jul 7, 2010 |
| Grant date | Apr 8, 2014 |
| Priority date | — |
| Expiry date | Jul 7, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed herein are methods of detecting blood disorders, such as diabetes. In particular examples the method includes contacting a blood sample with an amine reagent, blocking an excess of the amine reagent with a blocking reagent, digesting the modified blood sample with trypsin to produce a digested blood sample containing a plurality of glycated N-terminal peptides and non-glycated N-terminal peptides, then analyzing the digested blood sample with MALDI MS. Also provided are reagents for use in such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.