Generation of induced pluripotent stem cells from small volumes of peripheral blood
US8691574B2 · kind B2 · utility
15Cited by
5References
19Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 14, 2011 |
| Grant date | Apr 8, 2014 |
| Priority date | — |
| Expiry date | Aug 12, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.