Method for generating homoplasmic cells from heteroplasmic cells
US8691578B2 · kind B2 · utility
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Key dates
| Filing date | Dec 10, 2010 |
| Grant date | Apr 8, 2014 |
| Priority date | — |
| Expiry date | May 14, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01H1/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method includes providing a eukaryotic cell including mutant mtDNA in which there is at least one mutation in the mtDNA, allowing the cell to come into contact with an active oxygen species or a chemical species that generates such an active oxygen species in the cell (e.g., hydrogen peroxide) and thereby changing the percentage of mutant mtDNA (mitochondrial genomic DNA) in the cell as a result of the contact. Also featured are cells obtained by the above-described method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.